Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study.

ABSTRACT:

Purpose

To determine the relationship between refractive error and diabetic retinopathy (DR).

Design

Clinical trial.

Participants

Type I diabetes individuals with serial refractive error and DR stage measurements over 30 years in the Diabetes Control and Complications Trial (DCCT) and Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study.

Methods

Stage of DR was measured every 6 months from standard fundus photographs, and refractive error was measured annually during the 6.5 years of DCCT; then, both were staggered every fourth year during EDIC with the full cohort measured at EDIC years 4 and 10. Outcomes of DR were 2- or 3-step progression, presence of proliferative DR (PDR), clinically significant macular edema (CSME), diabetic mac

SUBMITTER: Hainsworth DP 

PROVIDER: S-EPMC7956062 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature