The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy.

ABSTRACT: Diabetic Retinopathy (DR) is a major cause of visual dysfunction, yet much remains unknown regarding the specific molecular events that contribute to diabetes-induced retinal pathophysiology. Herein, we review the impact of oxidative stress on DR, and explore evidence that supports a key role for the stress response protein regulated in development and DNA damage (REDD1) in the development of diabetes-induced oxidative stress and functional defects in vision. It is well established that REDD1 mediates the cellular response to a number of diverse stressors through repression of the central metabolic regulator known as mechanistic target of rapamycin complex 1 (mTORC1). A growing body of evidence also supports that REDD1 acts independent of mTORC1 to promote oxidative stress by both enhancin

SUBMITTER: Miller WP 

PROVIDER: S-EPMC7956244 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature