Injury-Induced Innate Immune Response During Segment Regeneration of the Earthworm, Eisenia andrei.

ABSTRACT: Regeneration of body parts and their interaction with the immune response is a poorly understood aspect of earthworm biology. Consequently, we aimed to study the mechanisms of innate immunity during regeneration in Eisenia andrei earthworms. In the course of anterior and posterior regeneration, we documented the kinetical aspects of segment restoration by histochemistry. Cell proliferation peaked at two weeks and remitted by four weeks in regenerating earthworms. Apoptotic cells were present throughout the cell renewal period. Distinct immune cell (e.g., coelomocyte) subsets were accumulated in the newly-formed blastema in the close proximity of the apoptotic area. Regenerating earthworms have decreased pattern recognition receptors (PRRs) (e.g., TLR, except for scavenger

SUBMITTER: Bodo K 

PROVIDER: S-EPMC7956685 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature