Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells.

ABSTRACT: Both cell and animal studies have shown that complete or partial deficiency of methionine inhibits tumor growth. Consequently, the potential implementation of this nutritional intervention has recently been of great interest for the treatment of cancer patients. Unfortunately, diet alteration can also affect healthy immune cells such as monocytes/macrophages and their precursor cells in bone marrow. As around half of cancer patients are treated with radiotherapy, the potential deleterious effect of dietary methionine deficiency on immune cells prior to and/or following irradiation needs to be evaluated. Therefore, we examined whether modulation of methionine content alters genetic stability in the murine RAW 264.7 monocyte/macrophage cell line in vitro by chromosomal analysis after 1-month

SUBMITTER: Binz RL 

PROVIDER: S-EPMC7956689 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature