Current Status of Angiogenic Cell Therapy and Related Strategies Applied in Critical Limb Ischemia.

ABSTRACT: Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease (PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated to atherosclerosis. Currently, revascularization strategies (bypass grafting, angioplasty) remain the first option for CLI patients, although less than 45% of them are eligible for surgical intervention mainly due to associated comorbidities. Moreover, patients usually require amputation in the short-term. Angiogenic cell therapy has arisen as a promising alternative for these "no-option" patients, with many studies demonstrating the potential of stem cells to enhance revascularization by promoting vessel formation and blood flow recovery in ischemic tissues. Herein, we provide an overview of studies focused

SUBMITTER: Beltran-Camacho L 

PROVIDER: S-EPMC7956816 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature