Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment.

ABSTRACT: Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic strategies have been developed for various cancers, including chemotherapy, radiotherapy, and immunotherapy, resistance to these treatments frequently impedes the clinical outcomes. Besides the active resistance driven by genetic and epigenetic alterations in tumor cells, the tumor microenvironment (TME) has also been reported to be a crucial regulator in tumorigenesis, progression, and resistance. Here, we propose that the adaptive mechanisms of tumor resistance are closely connected with the TME rather than depending on non-cell-autonomous changes in response to clinical treatment. Although the comprehensive understanding of adaptive mechanisms driven by the TME need further investigation to fully el

SUBMITTER: Wu P 

PROVIDER: S-EPMC7957022 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature