Impact of Oseltamivir Treatment on Influenza A and B Virus Dynamics in Human Volunteers.

ABSTRACT: Influenza viruses infect millions of humans every year causing an estimated 400,000 deaths globally. Due to continuous virus evolution current vaccines provide only limited protection against the flu. Several antiviral drugs are available to treat influenza infection, and one of the most commonly used drugs is oseltamivir (Tamiflu). While the mechanism of action of oseltamivir as a neuraminidase inhibitor is well-understood, the impact of oseltamivir on influenza virus dynamics in humans has been controversial. Many clinical trials with oseltamivir have been done by pharmaceutical companies such as Roche but the results of these trials until recently have been provided as summary reports or papers. Typically, such reports included median virus shedding curves for placebo and drug-treated i

SUBMITTER: Hooker KL 

PROVIDER: S-EPMC7957053 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature