Low expression of GSTP1 in the aqueous humour of patients with primary open-angle glaucoma.

ABSTRACT: Primary open-angle glaucoma (POAG) is characterized by irreversible neurodegeneration accompanied by visual field defects and high intraocular pressure. Currently, an effective treatment is not available to prevent the progression of POAG, other than treatments to decrease the high intraocular pressure. We performed proteomic analysis of aqueous humour (AH) samples from patients with POAG combined with cataract and patients with cataract to obtain a better understanding of the pathogenesis of POAG and explore potential treatment targets for this condition. Samples were collected from 10 patients with POAG combined with cataract and 10 patients with cataract. Samples from each group were pooled. A high-resolution, label-free, liquid chromatography-tandem mass spectrometry-based quantitative

SUBMITTER: Liu A 

PROVIDER: S-EPMC7957170 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature