An antitumor peptide RS17-targeted CD47, design, synthesis, and antitumor activity.

ABSTRACT:

Background

CD47 is a widely expressed transmembrane protein located on the surface of somatic cells. It mediates a variety of cellular processes including apoptosis, proliferation, adhesion, and migration. An important role for CD47 is the transmission of a "Don't eat me" signal by interacting with SIRPα on the macrophage surface membrane, thereby preventing the phagocytosis of normal cells. However, cancer cells can take advantage of this autogenous signal to protect themselves from phagocytosis, thus enabling immune escape. Blocking the interaction between CD47 and SIRPα has proven to be effective in removing cancer cells. The treatment of various cancers with CD47 monoclonal antibodies has also been validated.

Methods

We designed and synthesized a peptide (RS17), which ca

SUBMITTER: Wang X 

PROVIDER: S-EPMC7957188 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature