Loss to follow-up correction increased mortality estimates in HIV-positive people on antiretroviral therapy in Mozambique.

ABSTRACT:

Objectives

People living with human immunodeficiency virus (HIV) on antiretroviral therapy (ART) may be lost to follow-up (LTFU), which hampers the assessment of outcomes. We estimated mortality for patients starting ART in a rural region in sub-Saharan Africa and examined risk factors for death, correcting for LTFU.

Study design and setting

We analyzed data from Ancuabe, Mozambique, where patients LTFU are traced by phone and home visits. We used cumulative incidence functions to estimate mortality and LTFU. To correct for LTFU, we revised outcomes based on tracing data using different inverse probability weights (maximum likelihood, Ridge regression, or Bayesian model averaging). We fitted competing risk models to identify risk factors for death and LTFU.

Results

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SUBMITTER: Anderegg N 

PROVIDER: S-EPMC7957226 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature