Molecular modeling provides insights into the loading of sialic acid-containing antigens onto CRM₁₉₇: the role of chain flexibility in conjugation efficiency and glycoconjugate architecture.

ABSTRACT: Vaccination is the most cost-effective way to control disease caused by encapsulated bacteria; the capsular polysaccharide (CPS) is the primary virulence factor and vaccine target. Neisseria meningitidis (Nm) serogroups B, C, Y and W all contain sialic acid, a common surface feature of human pathogens. Two protein-based vaccines against serogroup B infection are available for human use while four tetravalent conjugate vaccines including serogroups C, W and Y have been licensed. The tetravalent Menveo® conjugate vaccine is well-defined: a simple monomeric structure of oligosaccharides terminally conjugated to amino groups of the carrier protein CRM₁₉₇. However, not only is there a surprisingly low limit for antigen chain attachment to CRM₁₉₇, but different serogroup sa

SUBMITTER: Kuttel MM 

PROVIDER: S-EPMC7957279 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature