COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disorders.

ABSTRACT: Psychiatric symptoms are seen in some COVID-19 patients, as direct or indirect sequelae, but it is unclear whether SARS-CoV-2 infection interacts with underlying neuronal or psychiatric susceptibilities. Such interactions might arise from COVID-19 immune responses, from infection of neurons themselves or may reflect social-psychological causes. To clarify this we sought the key gene expression pathways altered in COVID-19 also affected in bipolar disorder, post-traumatic stress disorder (PTSD) and schizophrenia, since this may identify pathways of interaction that could be treatment targets. We performed large scale comparisons of whole transcriptome data and immune factor transcript data in peripheral blood mononuclear cells (PBMC) from COVID-19 patients and patients with psychiatric diso

SUBMITTER: Moni MA 

PROVIDER: S-EPMC7957287 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature