Automated gesture tracking in head-fixed mice.

ABSTRACT:

Background

The preparation consisting of a head-fixed mouse on a spherical or cylindrical treadmill offers unique advantages in a variety of experimental contexts. Head fixation provides the mechanical stability necessary for optical and electrophysiological recordings and stimulation. Additionally, it can be combined with virtual environments such as T-mazes, enabling these types of recording during diverse behaviors.

New method

In this paper we present a low-cost, easy-to-build acquisition system, along with scalable computational methods to quantitatively measure behavior (locomotion and paws, whiskers, and tail motion patterns) in head-fixed mice locomoting on cylindrical or spherical treadmills.

Existing methods

Several custom supervised and unsupervised methods

SUBMITTER: Giovannucci A 

PROVIDER: S-EPMC7957302 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature