Insights into Interactions between Interleukin-6 and Dendritic Polyglycerols.

ABSTRACT: Interleukin-6 (IL-6) is involved in physiological and pathological processes. Different pharmacological agents have been developed to block IL-6 deleterious effects and to recover homeostatic IL-6 signaling. One of the proposed nanostructures in pre-clinical investigations which reduced IL-6 concentrations is polyglycerol dendrimer, a nano-structure with multiple sulfate groups. The aim of the present study was to uncover the type of binding between critical positions in the human IL-6 structure available for binding dPGS and compare it with heparin sulfate binding. We studied these interactions by performing docking simulations of dPGS and heparins with human IL-6 using AutoDock Vina. These molecular docking analyses indicate that the two ligands have comparable affinities for the positiv

SUBMITTER: Sanader Marsic Z 

PROVIDER: S-EPMC7957513 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature