Resveratrol Affects Insulin Signaling in Type 2 Diabetic Goto-Kakizaki Rats.

ABSTRACT: Resveratrol is a biologically active diphenolic compound exerting multiple beneficial effects in the organism, including anti-diabetic properties. This action is, however, not fully elucidated. In the present study, we examined effects of resveratrol on some parameters related to insulin signaling, and also on diabetes-associated dysregulation in Goto-Kakizaki (GK) rats with congenital type 2 diabetes. Resveratrol was given at the dose of 20 mg/kg b.w. for 10 weeks. It was shown that the expression and phosphorylation levels of insulin receptor in the skeletal muscle of GK rats were significantly decreased, compared with control animals. However, these changes were totally prevented by resveratrol. Liver expression of the insulin receptor was also reduced, but in this case, resveratrol was

SUBMITTER: Szkudelska K 

PROVIDER: S-EPMC7957525 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature