Angiogenesis in the Normal Adrenal Fetal Cortex and Adrenocortical Tumors.

ABSTRACT: Angiogenesis plays an important role in several physiological and pathological processes. Pharmacological angiogenesis modulation has been robustly demonstrated to achieve clinical benefits in several cancers. Adrenocortical carcinomas (ACC) are rare tumors that often have a poor prognosis. In addition, therapeutic options for ACC are limited. Understanding the mechanisms that regulate adrenocortical angiogenesis along the embryonic development and in ACC could provide important clues on how these processes could be pharmacologically modulated for ACC treatment. In this report, we performed an integrative review on adrenal cortex angiogenesis regulation in physiological conditions and ACC. During embryonic development, adrenal angiogenesis is regulated by both VEGF and Ang-Tie signaling pa

SUBMITTER: Pereira SS 

PROVIDER: S-EPMC7957756 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature