Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial.

ABSTRACT:

Objective

There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial.

Design

Data were extracted from an aspirin versus placebo primary prevention trial conducted throughout 2010-2017 ('ASPirin in Reducing Events in the Elderly (ASPREE)', n=19 114) in community-dwelling persons aged ≥70 years. Clinical characteristics were collected at baseline and annually. The endpoint was major GI bleeding that resulted in transfusion, hospitalisation, surgery or death, adjudicated independently by two physicians blinded to trial arm.

Results

Over a median follow-up of 4.7 years (88 389 person years), there were 137 upper GI bl

SUBMITTER: Mahady SE 

PROVIDER: S-EPMC7957959 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature