Association of ISL1 polymorphisms and eosinophilic levels among otitis media patients.

ABSTRACT:

Background

Otitis media (OM) is a middle ear inflammatory complex disorder involving genetic and environmental factors. It onsets during childhood and often recurs and perplexes in genetically susceptible patients. Previously, murine models had shown the association of ISL LIM homeobox 1 (ISL1) gene with otitis media with effusion.

Aim

To investigate the association of ISL1 genetic variants with otitis media.

Subjects and methods

A total of 285 cases and 277 controls were recruited for the study. The entire coding region of ISL1 gene was genotyped using Sanger sequencing or single-strand conformation polymorphism methods. Genotype, haplotype, in silico analysis, and linkage disequilibrium analysis were performed.

Results

The variants rs2303751 (c.504A>G) and rs

SUBMITTER: Kondyarpu A 

PROVIDER: S-EPMC7957994 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature