Volitional learning promotes theta phase coding in the human hippocampus.

ABSTRACT: Electrophysiological studies in rodents show that active navigation enhances hippocampal theta oscillations (4-12 Hz), providing a temporal framework for stimulus-related neural codes. Here we show that active learning promotes a similar phase coding regime in humans, although in a lower frequency range (3-8 Hz). We analyzed intracranial electroencephalography (iEEG) from epilepsy patients who studied images under either volitional or passive learning conditions. Active learning increased memory performance and hippocampal theta oscillations and promoted a more accurate reactivation of stimulus-specific information during memory retrieval. Representational signals were clustered to opposite phases of the theta cycle during encoding and retrieval. Critically, during active but not passive l

SUBMITTER: Pacheco Estefan D 

PROVIDER: S-EPMC7958181 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature