Comparative Efficacy and Tolerability of Adjunctive Pharmacotherapies for Acute Bipolar Depression: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Objective

We investigated the comparative efficacy and tolerability of augmentation strategies for bipolar depression.

Data sources

We conducted a systematic review and network meta-analysis of 8 electronic databases for double-blind, randomized controlled trials of adjunctive pharmacotherapies for acute bipolar depression.

Data extraction and synthesis

We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and applied the Cochrane risk of bias tool for study quality appraisal. Two reviewers independently abstracted data. We resolved all discrepancies by consensus.

Main outcomes and measures

Primary outcomes were response and completion of treatment. We estimated summary rate ratios (RRs) and standardized mean differences

SUBMITTER: Bahji A 

PROVIDER: S-EPMC7958200 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature