A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa.

ABSTRACT: The primary task of a spermatozoon is to deliver its nuclear payload to the egg to form the next-generation zygote. With polyandry repeatedly evolving in the animal kingdom, however, sperm competition has become widespread, with the highest known intensities occurring in fish. Yet, the molecular controls regulating spermatozoon swimming performance in these organisms are largely unknown. Here, we show that the kinematic properties of postactivated piscine spermatozoa are regulated through a conserved trafficking mechanism whereby a peroxiporin ortholog of mammalian aquaporin-8 (Aqp8bb) is inserted into the inner mitochondrial membrane to facilitate H₂O₂ efflux in order to maintain ATP production. In teleosts from more ancestral lineages, such as the zebrafish (Dani

SUBMITTER: Chauvigne F 

PROVIDER: S-EPMC7958246 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature