Detection of Inflammatory and Homeostasis Biomarkers after Selective Removal of Carious Dentin-An In Vivo Feasibility Study.

ABSTRACT: Deep carious dentin lesions induce an immune reaction within the pulp-dentin complex, leading to the release of cytokines, which might be suitable biomarkers in pulp diagnostics. This in vivo feasibility study determines the concentration of different cytokines after selective removal of carious infected dentin (SCR). In our methodology, paired samples are obtained from 21 patients-each of them with two deep carious lesions at posterior teeth without clinical symptoms. After SCR, lesions are randomly assigned to treatment strategy: Group 1 (11 patients): Carious dentin is covered either with Biodentine^TM (n = 11) or gutta-percha (n = 11) before using the adhesive Optibond^TM FL. Group 2 (10 patients): The adhesives Clearfil^TM SE Protect Bond (<

SUBMITTER: Schmidt J 

PROVIDER: S-EPMC7958315 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature