Splenectomy is associated with altered leukocyte kinetics after severe trauma.

ABSTRACT:

Background

Inadequate activation of the innate immune system after trauma can lead to severe complications such as Acute Respiratory Distress Syndrome and Multiple Organ Dysfunction Syndrome. The spleen is thought to modulate the cellular immune system. Furthermore, splenectomy is associated with improved outcome in severely injured trauma patients. We hypothesized that a splenectomy alters the cellular immune response in polytrauma.

Methods

All adult patients with an ISS ≥ 16 and suffering from splenic or hepatic injuries were selected from our prospective trauma database. Absolute leukocyte numbers in peripheral blood were measured. White blood cell kinetics during the first 14 days were compared between splenectomized patients, patients treated surgically for liver trauma

SUBMITTER: Teuben MPJ 

PROVIDER: S-EPMC7958390 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature