Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection.

ABSTRACT: We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

SUBMITTER: Song H 

PROVIDER: S-EPMC7958800 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature