A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker.

ABSTRACT: An early biomarker would transform our ability to screen and treat patients with cancer. The large amount of multi-scale molecular data in public repositories from various cancers provide unprecedented opportunities to find such a biomarker. However, despite identification of numerous molecular biomarkers using these public data, fewer than 1% have proven robust enough to translate into clinical practice. One of the most important factors affecting the successful translation to clinical practice is lack of real-world patient population heterogeneity in the discovery process. Almost all biomarker studies analyze only a single cohort of patients with the same cancer using a single modality. Recent studies in other diseases have demonstrated the advantage of leveraging biological and technica

SUBMITTER: Scott MKD 

PROVIDER: S-EPMC7958996 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature