Breast Cancer Brain Metastasis-Overview of Disease State, Treatment Options and Future Perspectives.

ABSTRACT: Breast cancer is the second most common origin of brain metastasis after lung cancer. Brain metastasis in breast cancer is commonly found in patients with advanced course disease and has a poor prognosis because the blood-brain barrier is thought to be a major obstacle to the delivery of many drugs in the central nervous system. Therefore, local treatments including surgery, stereotactic radiation therapy, and whole-brain radiation therapy are currently considered the gold standard treatments. Meanwhile, new targeted therapies based on subtype have recently been developed. Some drugs can exceed the blood-brain barrier and enter the central nervous system. New technology for early detection and personalized medicine for metastasis are warranted. In this review, we summarize the historical o

SUBMITTER: Watase C 

PROVIDER: S-EPMC7959316 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature