The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs.

ABSTRACT:

Background

Echinococcosis and cysticercosis are neglected tropical diseases caused by cestode parasites (family Taeniidae). Not only there is a small number of approved anthelmintics for the treatment of these cestodiases, but also some of them are not highly effective against larval stages, such that identifying novel drug targets and their associated compounds is critical. Histone deacetylase (HDAC) enzymes are validated drug targets in cancers and other diseases, and have been gaining relevance for developing new potential anti-parasitic treatments in the last years. Here, we present the anthelmintic profile for a panel of recently developed HDAC inhibitors against the model cestode Mesocestoides vogae (syn. M. corti).

Methodology/principal findings

Phenotypic screening w

SUBMITTER: Vaca HR 

PROVIDER: S-EPMC7959350 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature