Reliability of dried blood spot (DBS) cards in antibody measurement: A systematic review.

ABSTRACT:

Background

Increasingly, vaccine efficacy studies are being recommended in low-and-middle-income countries (LMIC), yet often facilities are unavailable to take and store infant blood samples correctly. Dried blood spots (DBS), are useful for collecting blood from infants for diagnostic purposes, especially in low-income settings, as the amount of blood required is miniscule and no refrigeration is required. Little is known about their utility for antibody studies in children. This systematic review aims to investigate the correlation of antibody concentrations against infectious diseases in DBS in comparison to serum or plasma samples that might inform their use in vaccine clinical trials.

Methods and findings

We searched MEDLINE, Embase and the Cochrane library for relevant

SUBMITTER: Amini F 

PROVIDER: S-EPMC7959368 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature