Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity.

ABSTRACT: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The etiology of MS is multifactorial, with disease risk determined by genetics and environmental factors. An emerging risk factor for immune-mediated diseases is an imbalance in the gut microbiome. However, the identity of gut microbes associated with disease risk, their mechanisms of action, and the interactions with host genetics remain obscure. To address these questions, we utilized the principal autoimmune model of MS, experimental autoimmune encephalomyelitis (EAE), together with a genetically diverse mouse model representing 29 unique host genotypes, interrogated by microbiome sequencing and targeted microbiome manipulation. We identified specific gut bacteria and their metabolic functions associated wit

SUBMITTER: Montgomery TL 

PROVIDER: S-EPMC7959502 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature