Broad distributions of transition-path times are fingerprints of multidimensionality of the underlying free energy landscapes.

ABSTRACT: Recent single-molecule experiments have observed transition paths, i.e., brief events where molecules (particularly biomolecules) are caught in the act of surmounting activation barriers. Such measurements offer unprecedented mechanistic insights into the dynamics of biomolecular folding and binding, molecular machines, and biological membrane channels. A key challenge to these studies is to infer the complex details of the multidimensional energy landscape traversed by the transition paths from inherently low-dimensional experimental signals. A common minimalist model attempting to do so is that of one-dimensional diffusion along a reaction coordinate, yet its validity has been called into question. Here, we show that the distribution of the transition path time, which is a common experim

SUBMITTER: Satija R 

PROVIDER: S-EPMC7959536 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature