IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria.

ABSTRACT: Enteropathogenic bacterial infections are a global health issue associated with high mortality, particularly in developing countries. Efficient host protection against enteropathogenic bacterial infection is characterized by coordinated responses between immune and nonimmune cells. In response to infection in mice, innate immune cells are activated to produce interleukin (IL)-23 and IL-22, which promote antimicrobial peptide (AMP) production and bacterial clearance. IL-36 cytokines are proinflammatory IL-1 superfamily members, yet their role in enteropathogenic bacterial infection remains poorly defined. Using the enteric mouse pathogen, C. rodentium, we demonstrate that signaling via IL-36 receptor (IL-36R) orchestrates a crucial innate-adaptive immune link to control bacter

SUBMITTER: Ngo VL 

PROVIDER: S-EPMC7959549 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature