Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice.

ABSTRACT: Occupational exposure to crystalline silica (cSiO₂) is etiologically associated with systemic lupus erythematosus (lupus) and other autoimmune diseases. cSiO₂'s autoimmune effects in humans can be mimicked chronically in female lupus-prone NZBWF1 mice following repeated exposure to the particle. However, the immediate and short-term effects of cSiO₂ in this widely used model of autoimmune disease are not well-understood. In the present study, we tested the hypothesis that a single acute cSiO₂ dose triggers early presentation of cellular, histopathological, transcriptomic, and protein biomarkers of inflammation and autoimmunity in lupus-prone mice. Eight-week old female NZBWF1 mice were intranasally instilled once with 2.5 mg cSiO₂ or s

SUBMITTER: Chauhan PS 

PROVIDER: S-EPMC7959771 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature