The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Autoimmune Disorders.

ABSTRACT: Extracellular vesicles (EVs) are important players in autoimmune diseases, both in disease pathogenesis and as potential treatments. EVs can transport autoimmune triggers throughout the body, facilitating the process of antigen presentation. Understanding the link between cellular stress and EV biogenesis and intercellular trafficking will advance our understanding of autoimmune diseases. In addition, EVs can also be effective treatments for autoimmune diseases. The diversity of cell types that produce EVs leads to a wide range of molecules to be present in EVs, and thus EVs have a wide range of physiological effects. EVs derived from dendritic cells or mesenchymal stem cells have been shown to reduce inflammation. Since many autoimmune treatments are focused only on symptom management, EV

SUBMITTER: Lu M 

PROVIDER: S-EPMC7959789 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature