Dietary Oxalate Loading Impacts Monocyte Metabolism and Inflammatory Signaling in Humans.

ABSTRACT: Diet has been associated with several metabolic diseases and may impact immunity. Increased consumption of meals with high oxalate content may stimulate urinary calcium oxalate (CaOx) crystals, which are precursors to CaOx kidney stones. We previously reported that CaOx stone formers have decreased monocyte cellular bioenergetics compared to healthy participants and oxalate reduces monocyte metabolism and redox status in vitro. The purpose of this study was to investigate whether dietary oxalate loading impacts monocyte cellular bioenergetics, mitochondrial complex activity, and inflammatory signaling in humans. Healthy participants (n = 40; 31.1 ± 1.3 years) with a BMI of 24.9 ± 0.6 kg/m² consumed a controlled low oxalate diet for 3 days before drinking a blended prepara

SUBMITTER: Kumar P 

PROVIDER: S-EPMC7959803 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature