APOE-ε4 Carrier Status and Gut Microbiota Dysbiosis in Patients With Alzheimer Disease.

ABSTRACT:

Background

Alternations in gut microbiota and a number of genes have been implicated as risk factors for the development of Alzheimer disease (AD). However, the interactions between the altered bacteria and risk genetic variants remain unclear.

Objective

We aimed to explore associations of the risk genetic variants with altered gut bacteria in the onset of AD.

Methods

We collected baseline data and stool and blood samples from 30 AD patients and 47 healthy controls in a case-control study. The rs42358/rs4512 (ApoE), rs3851179 (PICALM), rs744373 (BIN1), rs9331888 (CLU), rs670139 (MS4A4E), rs3764650 (ABCA7), rs3865444 (CD33), rs9349407 (CD2AP), rs11771145 (EPHA1), and rs3818361/rs6656401 (CR1) were se

SUBMITTER: Hou M 

PROVIDER: S-EPMC7959830 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature