Behavioral Time Scale Plasticity of Place Fields: Mathematical Analysis.

ABSTRACT: Traditional synaptic plasticity experiments and models depend on tight temporal correlations between pre- and postsynaptic activity. These tight temporal correlations, on the order of tens of milliseconds, are incompatible with significantly longer behavioral time scales, and as such might not be able to account for plasticity induced by behavior. Indeed, recent findings in hippocampus suggest that rapid, bidirectional synaptic plasticity which modifies place fields in CA1 operates at behavioral time scales. These experimental results suggest that presynaptic activity generates synaptic eligibility traces both for potentiation and depression, which last on the order of seconds. These traces can be converted to changes in synaptic efficacies by the activation of an instructive signal that d

SUBMITTER: Cone I 

PROVIDER: S-EPMC7959845 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature