Network Pharmacological Study of Achyranthis bidentatae Radix Effect on Bone Trauma.

ABSTRACT:

Purpose

Bone trauma is a clinical condition that afflicts the majority of the world's population. For the management of bone trauma, the underlying mechanisms of the drugs effective for bone healing are deemed necessary. Achyranthis bidentatae Radix (ABR) is a popular alternative medicine recommended in the treatment of bone trauma and injury, yet its mechanism of action persists to be vague. This study was conducted for the evaluation of the mode of action of ABR through network pharmacology in treating bone trauma.

Methods

An extensive survey of published works led to the development of a drug-target database, after which multiple protein targets for bone trauma were discerned. The protein-protein interaction network was developed by utilizing the STITCH database an

SUBMITTER: Wu L 

PROVIDER: S-EPMC7959927 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature