Basilar Artery Changes in Fabry Disease.

ABSTRACT:

Background and purpose

Dolichoectasia of the basilar artery is a characteristic finding of Fabry disease. However, its prevalence, severity, and course have been poorly studied. This study quantitatively evaluated, by MRA, a panel of basilar artery parameters in a large cohort of patients with Fabry disease.

Materials and methods

Basilar artery mean diameter, curved length, "origin-to-end" linear distance (linear length), and tortuosity index ([curved length ÷ linear length] - 1) were retrospectively measured on 1.5T MRA studies of 110 patients with Fabry disease (mean age, 39.4 ± 18.6 years; 40 males) and 108 control patients (mean age, 42.0 ± 18.2 years; 40 males).

Results

Patients with Fabry disease had increased basilar artery mean diameter (P < .001) and b

SUBMITTER: Manara R 

PROVIDER: S-EPMC7960013 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature