Diffusion Tensor Imaging of White Matter in Children Born from Preeclamptic Gestations.

ABSTRACT:

Background and purpose

Individuals born from pregnancies complicated by preeclampsia have an elevated risk for cognitive impairment. Deviations in maternal plasma angiokines occur for prolonged intervals before clinical signs of preeclampsia. We hypothesized that fetal brain vascular and nervous tissue development become deviated during maternal progression toward preeclampsia and that such deviations would be detectable by MR imaging.

Materials and methods

In this pilot study, 10 matched (gestational and current ages) pairs (5 boys/5 girls, 7-10 years of age) from preeclampsia or control pregnancies were examined by using diffusion tensor MR imaging. An unbiased voxel-based analysis was conducted on fractional anisotropy and mean diffusivity parametric maps. Six brain ROIs

SUBMITTER: Figueiro-Filho EA 

PROVIDER: S-EPMC7960234 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature