Identifying Significant Changes in Cerebrovascular Reactivity to Carbon Dioxide.

ABSTRACT:

Background and purpose

Changes in cerebrovascular reactivity can be used to assess disease progression and response to therapy but require discrimination of pathology from normal test-to-test variability. Such variability is due to variations in methodology, technology, and physiology with time. With uniform test conditions, our aim was to determine the test-to-test variability of cerebrovascular reactivity in healthy subjects and in patients with known cerebrovascular disease.

Materials and methods

Cerebrovascular reactivity was the ratio of the blood oxygen level-dependent MR imaging response divided by the change in carbon dioxide stimulus. Two standardized cerebrovascular reactivity tests were conducted at 3T in 15 healthy men (36.7 ± 16.1 years of age) within a 4-month

SUBMITTER: Sobczyk O 

PROVIDER: S-EPMC7960311 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature