Cognitive Implications of Deep Gray Matter Iron in Multiple Sclerosis.

ABSTRACT:

Background and purpose

Deep gray matter iron accumulation is increasingly recognized in association with multiple sclerosis and can be measured in vivo with MR imaging. The cognitive implications of this pathology are not well-understood, especially vis-à-vis deep gray matter atrophy. Our aim was to investigate the relationships between cognition and deep gray matter iron in MS by using 2 MR imaging-based iron-susceptibility measures.

Materials and methods

Forty patients with multiple sclerosis (relapsing-remitting, n = 16; progressive, n = 24) and 27 healthy controls were imaged at 4.7T by using the transverse relaxation rate and quantitative susceptibility mapping. The transverse relaxation rate and quantitative susceptibility mapping values and volumes (atro

SUBMITTER: Fujiwara E 

PROVIDER: S-EPMC7960387 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature