Backbone and side-chain chemical shift assignments of p50 subunit of NF-κB transcription factor.

ABSTRACT: Nuclear Factor κB (NF-κB) is a family of five related transcription factors that recognize a κB DNA element on the promoter and enhancer regions of target genes and modulate their expression. Here we report a complete set of ¹H, ¹³C, ¹⁵N backbone and side chain resonance assignments for the p50 DNA binding and dimerization domains of the p50 homodimer form of the NF-κB transcription factor. The chemical shift data constitute a first step towards understanding the mechanism of interaction of the p50 homodimer with DNA.

SUBMITTER: Singh A 

PROVIDER: S-EPMC7960568 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature