Strategies Towards Improving Clinical Outcomes of Peptide Receptor Radionuclide Therapy.

ABSTRACT:

Purpose of review

Peptide receptor radionuclide therapy (PRRT) with [¹⁷⁷Lu-DOTA⁰,Tyr³] octreotate is an effective and safe second- or third-line treatment option for patients with low-grade advanced gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN). In this review, we will focus on possible extensions of the current use of PRRT and on new approaches which could further improve its treatment efficacy and safety.

Recent findings

Promising results were published regarding PRRT in other NENs, including lung NENs or high-grade NENs, and applying PRRT as neoadjuvant or salvage therapy. Furthermore, a diversity of strategic approaches, including dosimetry, somatostatin receptor antagonists, somatostatin receptor upregulation, radiosensitiz

SUBMITTER: Minczeles NS 

PROVIDER: S-EPMC7960621 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature