A Raman algorithm to estimate human age from protein structural variations in autopsy skin samples: a protein biological clock.

ABSTRACT: The recent increase of the number of unidentified cadavers has become a serious problem throughout the world. As a simple and objective method for age estimation, we attempted to utilize Raman spectrometry for forensic identification. Raman spectroscopy is an optical-based vibrational spectroscopic technique that provides detailed information regarding a sample's molecular composition and structures. Building upon our previous proof-of-concept study, we measured the Raman spectra of abdominal skin samples from 132 autopsy cases and the protein-folding intensity ratio, R_PF, defined as the ratio between the Raman signals from a random coil an α-helix. There was a strong negative correlation between age and R_PF with a Pearson correlation coefficient of r = 0.878. Four mo

SUBMITTER: Miyamori D 

PROVIDER: S-EPMC7960715 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature