A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing.

ABSTRACT: Effective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Transforming growth factor-β (TGFβ) signaling exerts pleiotropic effects on wound healing by regulating cell proliferation, migration, ECM production, and the immune response. Although blocking TGFβ signaling can reduce tissue fibrosis and scarring, systemic inhibition of TGFβ can lead to significant side effects and inhibit wound re-epithelization. In this study, we develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsu

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7960722 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature