Adoptive Transfer of Regulatory Immune Cells in Organ Transplantation.

ABSTRACT: Chronic graft rejection remains a significant barrier to solid organ transplantation as a treatment for end-organ failure. Patients receiving organ transplants typically require systemic immunosuppression in the form of pharmacological immunosuppressants for the duration of their lives, leaving these patients vulnerable to opportunistic infections, malignancies, and other use-restricting side-effects. In recent years, a substantial amount of research has focused on the use of cell-based therapies for the induction of graft tolerance. Inducing or adoptively transferring regulatory cell types, including regulatory T cells, myeloid-derived suppressor cells, and IL-10 secreting B cells, has the potential to produce graft-specific tolerance in transplant recipients. Significant progress has bee

SUBMITTER: Oberholtzer N 

PROVIDER: S-EPMC7960772 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature