Severe Altered Immune Status After Burn Injury Is Associated With Bacterial Infection and Septic Shock.

ABSTRACT: Introduction: Burn injury is associated with a high risk of death. Whether a pattern of immune and inflammatory responses after burn is associated with outcome is unknown. The aim of this study was to explore the association between systemic immune and inflammatory responses and outcome in severely-ill burn patients. Materials and Methods: Innate immunity, adaptive immunity, activation and stress and inflammation biomarkers were collected at admission and days 2, 7, 14, and 28 in severely-ill adult burn patients. Primary endpoint was mortality at day 90, secondary endpoint was secondary infections. Healthy donors (HD) served as controls. Multiple Factorial Analysis (MFA) was used to identify patterns of immune response. Results: 50 patients were included. Age was 49.2

SUBMITTER: Moins-Teisserenc H 

PROVIDER: S-EPMC7960913 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature