Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches.

ABSTRACT: Over the years, conventional cancer treatments, such as chemotherapy with only a limited specificity for tumors, have undergone significant improvement. Moreover, newer therapies such as immunotherapy have undergone a revolution to stimulate the innate as well as adaptive immune responses against the tumor. However, it has been found that tumors can be selectively colonized by certain bacteria, where they can proliferate, and exert direct oncolytic effects as well as stimulating the immune system. Bacterial-mediated cancer therapy (BMCT) is now one example of a hot topic in the antitumor field. Salmonella typhimurium is a Gram-negative species that generally causes self-limiting gastroenteritis in humans. This species has been designed and engineered in order to be used in cancer-ta

SUBMITTER: Badie F 

PROVIDER: S-EPMC7960920 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature