Small compounds mimicking the adhesion molecule L1 improve recovery in a zebrafish demyelination model.

ABSTRACT: Demyelination leads to a loss of neurons, which results in, among other consequences, a severe reduction in locomotor function, and underlies several diseases in humans including multiple sclerosis and polyneuropathies. Considerable clinical progress has been made in counteracting demyelination. However, there remains a need for novel methods that reduce demyelination while concomitantly achieving remyelination, thus complementing the currently available tools to ameliorate demyelinating diseases. In this study, we used an established zebrafish demyelination model to test selected compounds, following a screening in cell culture experiments and in a mouse model of spinal cord injury that was aimed at identifying beneficial functions of the neural cell adhesion molecule L1. In comparison to

SUBMITTER: Kim S 

PROVIDER: S-EPMC7960995 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature