Computational modeling reveals a key role for polarized myeloid cells in controlling osteoclast activity during bone injury repair.

ABSTRACT: Bone-forming osteoblasts and -resorbing osteoclasts control bone injury repair, and myeloid-derived cells such as monocytes and macrophages are known to influence their behavior. However, precisely how these multiple cell types coordinate and regulate each other over time within the bone marrow to restore bone is difficult to dissect using biological approaches. Conversely, mathematical modeling lends itself well to this challenge. Therefore, we generated an ordinary differential equation (ODE) model powered by experimental data (osteoblast, osteoclast, bone volume, pro- and anti-inflammatory myeloid cells) obtained from intra-tibially injured mice. Initial ODE results using only osteoblast/osteoclast populations demonstrated that bone homeostasis could not be recovered after injury, but t

SUBMITTER: Lo CH 

PROVIDER: S-EPMC7961065 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature